Analysis Note

ControlExpressed in lung, placental stem villi vessels and in cultured placental vascular smooth muscle cells

Application

Research CategoryNeuroscience

Development of Immunoradiometric assay (IRMA) for endothelin ET-1 which as a circulating plasma peptide has been associated with a variety of disease studies such as diabetes, hypertension, cardiogenic shock, acute myocardial infarction and uraemia.

Suitable for immunohistochemistry on frozen sections

Optimal working dilutions must be determined by the end user.

Research Sub CategoryCNS Control of MetabolismHormones & Receptors

Detect Endothelin-1 using this Anti-Endothelin-1 Antibody, clone IC4 validated for use in IC.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Physical form

Protein A purified

Format: Purified

Liquid in 0.02 M PBS with 0.25 M NaCl, pH 7.6. Contains 0.1% sodium azide.

Specificity

Recognizes endothelin ET-1 (10% cross-reactivity with ET-3) and when used in conjunction with CBL87 (anti-endothelin C-terminus) has a sensitivity of 0.06 pmol/L for ET-1.

Storage and Stability

For use within 1 month of purchase when stored at +4°C, for long-term storage, aliquot antibody into small volumes and store at -20°C.